再生护肤品——脐带间充质干细胞外泌体行业先锋

脐带间充质干细胞提取物：皮肤再生医学的研究前沿

在护肤科技持续演进的背景下，来自再生医学领域的研究成果正在为皮肤护理提供新的思路。脐带间充质干细胞来源的外泌体（UC-MSC-Exos）作为细胞间信息传递的重要载体，近年来受到了国际皮肤科学和再生医学领域的广泛关注。本文将从科学研究的角度，梳理这一领域的研究进展与初步发现。

一、什么是脐带提取物？——细胞间通讯的重要媒介

脐带提取物是细胞分泌的纳米级囊泡结构，直径约在30至150纳米之间，携带蛋白质、脂质、mRNA和miRNA等多种生物活性分子。

研究表明，脐带提取物在细胞间信息传递中扮演着重要角色——它们从“母细胞”出发，将特定的生物信号递送至目标细胞，从而调节受体细胞的功能活动。这一特性使脐带提取物成为再生医学研究的热点方向之一。

二、脐带来源的优势：比较研究的发现

不同类型间充质干细胞分泌的脐带提取物具有不同的生物学特性。根据2026年发表于《Aesthetic Surgery Journal》的一项比较研究，脐带来源（UC-MSC）与脂肪来源（AD-MSC）的脐带提取物展现出“生物学上不同、临床上趋同”的再生潜力。

研究发现：

• AD-MSC脐带提取物：血管内皮生长因子（VEGF）含量较高，在促进胶原蛋白和透明质酸合成方面表现突出
• UC-MSC脐带提取物：富含转化生长因子-β和血小板衍生生长因子-BB，具有更强的免疫调节活性，在紫外线损伤皮肤模型中表现出更显著的衰老相关分泌表型抑制作用

研究者认为，这两种来源的脐带提取物具有互补的再生特性，未来可基于不同皮肤问题选择差异化的脐带提取物来源。

三、作用机制：多途径的皮肤细胞调节

3.1 促进成纤维细胞增殖与迁移

成纤维细胞是真皮层中负责合成胶原蛋白和细胞外基质的关键细胞。体外实验研究显示，人脐带间充质干细胞来源的外泌体可被人皮肤成纤维细胞和人脐静脉内皮细胞有效摄取，显著促进成纤维细胞的增殖与迁移能力。

3.2 调节炎症反应与促进血管新生

在皮肤损伤动物模型中，UC-MSC-Exos通过降低炎症因子水平、刺激血管新生，显著加速了伤口愈合进程。生物信息学分析提示，ULK2、COL19A1、IL6ST等可能是UC-MSC-Exos调控皮肤修复的关键分子靶点。

3.3 对黑色素合成的影响

一项发表于《International Journal of Nanomedicine》的研究探讨了UC-MSC-Exos对皮肤色素合成的影响。该研究发现，UC-MSC-Exos以剂量依赖的方式减少黑色素合成，且未观察到对酪氨酸酶活性的直接影响。

研究者认为，UC-MSC-Exos在减少疤痕、皮肤再生和肤色提亮方面具有研究价值和应用潜力。

四、原料合规进展：国际化妆品原料备案

在产业化应用方面，脐带间充质干细胞提取物已取得重要合规进展。2026年1月，上海原天生物科技有限公司自主研发的OriExo®人脐带间充质干细胞提取物正式通过国际化妆品原料命名委员会（INCI）备案，被纳入全球化妆品原料名录。

这意味着该原料获得了国际通行的“身份标识”，可以在全球范围内按照化妆品原料标准进行规范的研发与应用。

五、未来展望

脐带间充质干细胞外泌体作为再生医学与皮肤科学交叉领域的研究热点，已在细胞生物学层面展现出多方面的研究价值。随着基础研究的深入、制备工艺的标准化以及监管政策的完善，这一研究方向有望为皮肤健康领域带来更多科学、安全的解决方案。

Regenerative Skincare – Pioneering the Umbilical Cord Mesenchymal Stem Cell Exosome Industry

Umbilical Cord Mesenchymal Stem Cell Extract: A Frontier in Skin Regenerative Medicine
Against the backdrop of continuous advancements in skincare technology, research findings from regenerative medicine are offering new insights into skin care. Exosomes derived from umbilical cord mesenchymal stem cells (UC-MSC-Exos), serving as key carriers for intercellular communication, have recently attracted significant attention in international dermatology and regenerative medicine. This article will review the research progress and initial discoveries in this field from a scientific perspective.
What is umbilical cord extract?—A crucial medium for intercellular communication
Cord blood extract consists of nanoscale vesicular structures secreted by cells, with diameters ranging from approximately 30 to 150 nanometers, carrying various bioactive molecules such as proteins, lipids, mRNA, and miRNA.
Research has shown that umbilical cord extracts play a significant role in intercellular communication—transmitting specific biological signals from “mother cells” to target cells, thereby regulating the functional activities of recipient cells. This property has made umbilical cord extracts one of the key areas of focus in regenerative medicine research.
II. Advantages of Cord Blood: Findings from Comparative Studies
Umbilical cord extracts derived from different types of mesenchymal stem cells exhibit distinct biological characteristics. According to a comparative study published in the Aesthetic Surgery Journal in 2026, umbilical cord-derived (UC-MSC) and adipose-derived (AD-MSC) umbilical cord extracts demonstrate “biologically distinct yet clinically convergent” regenerative potential.
Research has found:
AD-MSC umbilical cord extract: high in vascular endothelial growth factor (VEGF), excelling in promoting collagen and hyaluronic acid synthesis
UC-MSC umbilical cord extract: rich in transforming growth factor-β and platelet-derived growth factor-BB, exhibits stronger immunomodulatory activity and demonstrates more significant suppression of senescence-associated secretory phenotype in ultraviolet radiation-damaged skin models.
Researchers believe that umbilical cord extracts from these two sources have complementary regenerative properties, and in the future, different sources of umbilical cord extract could be selected based on specific skin conditions.
III. Mechanism of Action: Multifaceted Regulation of Skin Cells
3.1 Promoting fibroblast proliferation and migration
Fibroblasts are key cells in the dermis responsible for synthesizing collagen and extracellular matrix. In vitro studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells can be efficiently taken up by human skin fibroblasts and human umbilical vein endothelial cells, significantly enhancing fibroblast proliferation and migration capacity.
3.2 Regulating Inflammatory Responses and Promoting Angiogenesis
In a skin injury animal model, UC-MSC-Exos significantly accelerated the wound healing process by reducing inflammatory factor levels and promoting angiogenesis. Bioinformatics analysis suggested that ULK2, COL19A1, IL6ST, and others may be key molecular targets regulated by UC-MSC-Exos in skin repair.
3.3 Effect on Melanin Synthesis
A study published in the International Journal of Nanomedicine investigated the effects of UC-MSC-Exos on skin pigment synthesis. The study found that UC-MSC-Exos reduced melanin production in a dose-dependent manner, with no direct effect observed on tyrosinase activity.
Researchers believe that UC-MSC-Exos have research value and application potential in reducing scarring, promoting skin regeneration, and improving skin tone.
IV. Raw Material Compliance Progress: International Cosmetic Ingredient Registration
In terms of industrial applications, umbilical cord mesenchymal stem cell extract has made significant regulatory progress. In January 2026, OriExo® human umbilical cord mesenchymal stem cell extract, independently developed by Shanghai Yuantian Biotechnology Co., Ltd., was officially registered with the International Nomenclature of Cosmetic Ingredients (INCI) and included in the global cosmetic ingredient directory.
This means the raw material has obtained internationally recognized “identity certification,” enabling its standardized research and application worldwide in accordance with cosmetic ingredient standards.
V. Future Outlook
Umbilical cord mesenchymal stem cell-derived exosomes, as a research hotspot at the intersection of regenerative medicine and dermatology, have demonstrated significant scientific value at the cellular level. With advancing basic research, standardized production methods, and improved regulatory frameworks, this field holds promise for delivering more scientifically sound and safe solutions to skin health.